Naricha Chirakalwasan, Busarakum Teerapraipruk, Lalitha Pereirasamy

Abstract
Introduction: Our prior investigation found positional sleep apnea accounting for approximately 70% of Asian obstructive sleep apnea patients. We hypothesized that the habitual side sleeping may indicate an obstructive sleep apnea deterring mechanism.

Naricha Chirakalwasan, M.D.; Busarakum Teerapraipruk, M.D.; Rosalind Simon, M.D.; Prakobkiat Hirunwiwatkul, M.D.; Nattapong Jaimchariyatam, M.D.; Tayard Desudchit, M.D.; Natamon Charakorn, M.D.; Chaisiri Wanlapakorn, M.D.

Introduction: Unlike Caucasians, many Asians with obstructive sleep apnea (OSA) are non-obese but are affected by the disease due to predisposing craniofacial structure. Therefore, non-obese and obese OSA may represent different disease entities. The associated risk factors for developing cardiovascular-related diseases, consequently, may be considered separately for the two types of OSA.

Rosalind Simon MD, Naricha Chirakalwasan MD, Busarakum Teerapraipruk MD, Prakobkiat Hirunwiwatkul MD, Nattapong Jaimchariyatam MD, Tayard Desudchit MD,
Natamon Charakorn MD, and Chaisiri Wanlapakorn MD

BACKGROUND: Previous studies have often investigated the association of obstructive sleep apnea (OSA) with cardiovascular morbidity and mortality, but the possibility of reverse causation has not been clearly defined.

OBJECTIVE: To examine if the presence of any of the cardiovascular-related diseases, including hypertension, diabetes mellitus, coronary artery disease, and/or cerebrovascular disease, correlates with more severe OSA.

Nattapong Jaimchariyatam, M.D., M.Sc.; Raed A. Dweik, M.D.; Roop Kaw, M.D.; Loutfi S. Aboussouan, M.D., F.A.A.S.M.

Study Objectives:Identify polysomnographic and demographic factors associated with elevation of nocturnal end-tidal CO2 n patients with obstructive sleep apnea.

Naricha Chirakalwasan, MD ; Deborah L. Ruzicka, RN, PhD; Joseph W. Burns, PhD; Ronald D. Chervin, MD, MS

Study Objectives:Respiratory cycle-related electroencephalographic (EEG) changes (RCREC), especially in delta and sigma frequencies, are thought to reflect subtle, breath-to-breath inspiratory microarousals that are exacerbated in association with increased work of breathing in obstructive sleep apnea (OSA). We wondered whether snoring sounds could create these microarousals, and investigated whether earplugs, anticipated to alter snoring perception, might affect RCREC.

Nattapong Jaimchariyatam, Carlos L. Rodriguez, Kumar Budur

Abstract

Objectives:Obstructive sleep apnea (OSA) is associated with significant cardiovascular (CV) morbidity. Continuous positive airway pressure (CPAP) is the standard treatment for moderate to severe OSA, resulting in a reduction in CV morbidity. No studies have compared CV outcomes between CPAP and no CPAP in mild OSA (5PAHI < 15).

Busarakum Teerapraipruk&Naricha Chirakalwasan& Rosalind Simon&Prakobkiat Hirunwiwatkul& Nattapong Jaimchariyatam&Tayard Desudchit& Natamon Charakorn&Chaisiri Wanlapakorn

Abstract
Introduction In Asian population, facial structure may contribute to the primary pathophysiology of obstructive sleep apnea (OSA). We hypothesized that sleep position may have more effect on OSA in Asians compared to the Western population. If this hypothesis is accurate, positional therapy will have a major impact on treatment of OSA among Asians. Patients/methodsWe reviewed 263 polysomnographic studies from our laboratory from January 1, 2010 to June 30, 2010. Criteria for positional and non-positional OSAwere (1) supine respiratory disturbance index (RDI)/non-supine RDI≥2 and total RDI ≥5 and (2) supine RDI/non-supine RDI <2 and total RDI ≥5, respectively. We aimed to determine the difference in baseline characteristics, polysomnographic findings, and predictors for positional OSA.

by NATTAPONG JAIMCHARIYATAM, MD, MSc, FCCP; CARLOS L. RODRIGUEZ, MD; and KUMAR BUDUR, MD, MS

ABSTRACT

Objective.

Major depressive disorder is associated with sleep disturbances. An electroencephalographic pattern of alpha wave intrusion in delta wave sleep (alpha-delta sleep) is observed in some subjects with major depressive disorder. The treatmentresistant symptoms in major depressive disorder, nonrestorative sleep and fatigue, are associated with alpha-delta sleep. The objective of this study is to identify the prevalence and clinical correlates of alpha-delta sleep in major depressive disorder.